In total, 43% of the patients were smokers. Patients with postoperative strictures were less frequently on anti-TNF therapy (17%, p = 0.023), thiopurines (34%, p = 0.001), and combination therapy (24%, p = 0.001) before surgery, and only 61% were on thiopurines at the time of postoperative colonoscopy (p = 0.040). In CD patients

with postoperative strictures, MAPK inhibitor 32% were symptomatic, 68% had an anastomotic stricture, and 18% had an ileal stricture. Endoscopic balloon dilatation was performed in 75% of patients (n = 30) with postoperative strictures, without any procedure complication, with a mean of two dilatations per patient, and mean time between dilatations of 7 ± 4 months. There were no differences between patients with postoperative strictures that were dilatated (n = 30) or not (n = 10), concerning hospital admission and new surgery. CD patients without anti-TNF therapy (OR 5.2 p = 0.033) or thiopurines (OR 5.3, p = 0.002) before surgery and without thiopurines (OR 2.21, p = 0.042) after surgery were at risk for postoperative strictures. Combination therapy before surgery was protective (OR 0.08, p = 0.001). There were no statistically significant differences for sex, Montreal classification, smoking, disease onset time until surgery and time until colonoscopy. Conclusion: Anti-TNF and/or thiopurines therapy before surgery

and thiopurines after surgery AZD6738 上海皓元医药股份有限公司 are protective factors for postoperative stricture development in patients with Crohn’s disease. Key Word(s): 1. Crohn disease; 2. stricture; 3. surgery; 4. balloon dilatation;

Presenting Author: DUMINDA SUBASINGHE Additional Authors: NAVARATHNA MUDIYANSELAGEMETHTHANANDA NAVARATHNA, DHARMABANDUNANDADEVA SAMARASEKERA Corresponding Author: DUMINDA SUBASINGHE Affiliations: Department of Surgery, The National Hospital of Sri Lanaka Objective: Ulcerative colitis (UC) and Crohn’s disease (CD) are chronic inflammatory conditions related to the gastrointestinal tract. Faecal incontinence (FI) impairs quality of life (QOL), causing embarrassment and limiting daily activities. FI can have a negative impact on the QOL of patients with inflammatory bowel disease (IBD). There is limited published data on FI amongst people with IBD in South Asia. This study looks at the frequency and severity of FI, and its effect on the QOL in IBD patients who presented to a tertiary care center. Methods: Patients with an established diagnosis of IBD were identified and demographics, disease characteristics, FI (Vaizey score), quality of life (IBD-Q) were collected. Data were analyzed using SPSS version 15. Results: A total of 184 patients (women = 101, 54.9%; UC = 153, 83.2%) were included. Female preponderance was observed for UC (male/female ratio = 1 : 1.5) and male for CD (male/female = 2 : 1). Forty eight (26%) reported symptoms of FI.