05) Table 5 Summary oxygen consumption (VO2, L/min) measures Autophagy Compound Library cell line resulting from five upper body power PCI-34051 datasheet tests Group Test Period Constant Power Test UBP10 Test
Trial #1 UBP10 Test Trial #2 UBP10 Test Trial #3 UBP60 Test Placebo (n = 12) Pre-Test 2.68 ± 0.28 2.29 ± 0.22 2.55 ± 0.20 2.63 ± 0.19 3.14 ± 0.24 Post-Test 2.72 ± 0.30 2.47 ± 0.23 2.88 ± 0.23 2.74 ± 0.21 ‡3.38 ± 0.26 Treatment (n = 12) Pre-Test 2.84 ± 0.29 2.34 ± 0.18 2.61 ± 0.17 2.65 ± 0.19 3.43 ± 0.25 Post-Test †2.77 ± 0.28 2.33 ± 0.21 2.67 ± 0.23 2.68 ± 0.20 ‡3.26 ± 0.26 NOTE: All values expressed as Mean ± SE; UBP10 = 10-sec Crenolanib upper body power test; UBP60 = 60-sec upper body power test †Post-test measure of VO2 for Constant -Power test was nearly significantly lower than pre-test measure within the treatment group (P < 0.10) ‡Post-test measure of VO2 for UBP60 test were significantly different than pre-test measure within the corresponding test group (P < 0.05) Table 6 Summary minute ventilation (VE,
L/min) measures resulting from five upper body power tests Group Test Period Constant Power Test UBP10 Test Trial #1 UBP10 Test Trial #2 UBP10 Test Trial #3 UBP60 Test Placebo (n = 12) Pre-Test 100.6 ± 11.5 87.9 ± 10.0 99.4 ± 10.2 110.4 ± 9.4 147.2 ± 12.1 Post-Test 100.7
± 13.2 92.3 ± 9.9 109.8 ± 9.9 113.9 ± 10.1 148.6 ± 13.2 Treatment (n = 12) Pre-Test 104.6 ± 11.7 102.9 ± 7.7 126.0 ± 12.8 129.7 ± 10.3 163.5 ± 12.0 Post-Test 101.7 ± 10.6 97.3 ± 9.8 122.4 ± 11.8 132.1 ± 12.9 †153.3 ± 11.1 NOTE: All values expressed as Mean ± SE; UBP10 = 10-sec upper body power test; UBP60 = 60-sec upper body power test †Post-test measure of VE for UPB60 test was nearly significantly lower than pre-test measures within the treatment group Branched chain aminotransferase (P < 0.10) Blood lactate measures Summary statistics for blood lactate measured at eight separate time points (L1-L8) are shown in Table 7. Pre- and post-testing lactate values were statistically similar for the first seven time points for the placebo group. The placebo group’s post-testing value for the eighth time (L8) point was significantly higher than the pre-testing value (10.3 ± 0.6 vs 9.7 ± 0.6 mmol/L). Pre- and post-testing values for the treatment group were also statistically similar for L2-L6, but post-testing values for L1, L7, and L8 were all statistically lower than their corresponding pre-testing values.