814 2 814 2 814 2 814 Total radiotherapy cost per patient with an

814 2.814 2.814 2.814 Total radioATR inhibitor therapy cost per patient with any radiotherapy per month (€ 2009) Mean 200 500 200 500   95% CI 100-200 300-700 100-300 0-1.100 Total radiotherapy

cost per patient (€ 2009) Mean 506 372 248 603 (1) month of follow-up. Transfusion Transfusions were relatively rare, with 3.8% of all patients who received systemic therapy also receiving a transfusion. Consequently the mean cost for the generality of the sample is very low (€ 12). Surgery 24% of patients received surgery in combination with systemic therapy (Table 10). Surgery was more common in patients who had any response to systemic therapy (30.35%) as compared selleck inhibitor with those with no response (19,3%) (Tables 11 and 12). Surgery was among the

most expensive categories of resource utilization, with a mean cost of € 7,390 per patient with any surgery. With reference to the generality of the sample, mean cost per patient with any CA3 purchase response was equal to € 2,312, which is higher than the cost per patient with no response (€ 1.376). Table 10 Summary statistics for surgery for patients receiving systemic therapy     Overall First-line therapy Second-line therapy Third-line therapy N   208 147 112 41 Patients with any surgery N 50 36 18 5   % 24,0% 24,5% 16,1% 12,2% Type of surgery Resection of primary tumor % 9% 9% 0% 0% Lymph node resection ADAMTS5 % 21% 16% 3% 2% All other visceral % 22% 12% 7% 3% Brain metastases % 9% 5%

3% 1% Isolated limb perfusion % 0% 0% 0% 0% Biopsy % 12% 9% 2% 1% Distant skin, subcutaneous or node % 12% 9% 3% 0% Lung % 1% 1% 0% 0% Total surgery cost per patient with any surgery (€ 2009) Mean 7.390 6.368 5.670 7.638 Total surgery cost per patient (€ 2009) Mean 1.776 1.560 911 931 Table 11 Summary statistics for surgery for patients with any response to systemic therapy     Overall First-line therapy Second-line therapy Third-line therapy N   89 53 34 14 Patients with any surgery N 27 13 8 2   % 30,3% 24,5% 23,5% 14,3% Type of surgery Resection of primary tumor % 6% 6% 0% 0% Lymph node resection % 11% 7% 1% 1% All other visceral % 12% 5% 4% 0% Brain metastases % 5% 3% 1% 1% Isolated limb perfusion % 0% 0% 0% 0% Biopsy % 6% 3% 1% 0% Distant skin, subcutaneous or node % 5% 3% 1% 0% Lung % 1% 1% 0% 0% Total surgery cost per patient with any surgery (€ 2009) Mean 7.621 9.070 5.778 7.426 Total surgery cost per patient (€ 2009) Mean 2.312 2.225 1.360 1.

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