Future longitudinal studies are recommended to clarify the effect of schizotypy on the clinical course of OCD.”
“P>Background:

Hyperleukocytosis (a white cell count in peripheral blood > 100 x 109 l-1) is a well-recognized medical emergency. Rates of morbidity associated with anesthesia in hyperleukocytotic patients

have not been previously described. This retrospective study describes the perioperative morbidity and mortality of children who present acutely with hyperleukocytosis.

Methods:

All patients under 17 years of age with leukemia complicated by hyperleukocytosis and who received general anesthesia as part of their acute care at the Children’s Hospital in Westmead from July 1999 to Pim inhibitor June 2008 were included. Data describing perioperative adverse events within 48 h of anesthesia were collected using a systematic chart review.

Results:

Over the 8- year period, 60 children were admitted with hyperleukocytosis related to a new diagnosis of leukemia. Fifty-two APR-246 clinical trial children had general anesthesia within 48 h of their admission. Eleven children required two separate general anesthetics within this same time frame. Two deaths were recorded within 48 h of anesthesia; one child died from neurological complications of her disease, and the second died from multi-organ failure. Three children had serious respiratory adverse events requiring postanesthesia intensive care. Thirteen children had notable but less serious

adverse events. These were typically respiratory in nature and required supplemental oxygen for more than 2 h after anesthesia.

Conclusion:

Children with leukemia-related hyperleukocytosis often require general anesthesia at the time of presentation and are at significant perioperative risk. Respiratory adverse events are very common and mandate close postanesthesia care.”
“Background: Borg developed scales for rating pain and perceived PLX4032 supplier exertion in adults

that have also been used in pediatric populations. Models describing functional relationships between perceived exertion and work capacity have not been studied in children. We compared different models and their fits to individual trajectories and assessed the variability in these trajectories.

Methods: Ratings of perceived exertion (RPE) were collected from 79 children. Progressive cycle ergonometric testing was performed to maximal work capacity with test duration ranging from 6- 12 minutes. Ratings were obtained during each 1-minute increment. Work was normalized to individual maximal work capacity (Wmax). A delay was defined as the fraction of Wmax at which point an increase in ratings of leg fatigue occurred. Such a delay term allows the characterization of trajectories for children whose ratings were initially constant with increasing work. Two models were considered, a delay model and a power model that is commonly used to analyze Borg ratings. Individual model fit was assessed with root mean squared error (RMSE).