Quantitative variables are expressed as the mean (± standard erro

Quantitative variables are expressed as the mean (± standard error), or median and range, and qualitative variables as absolute and relative frequencies. Comparisons between groups of quantitative and qualitative variables were made by the Wilcoxon and chi square tests, respectively. Recanalization rates were AG-014699 molecular weight assessed using Cox models. Independent predictive factors for lack of recanalization were

assessed with Cox model regression. Overall survival rates were assessed by the Kaplan-Meier method. Comparisons of recanalization rates with risk factors were made by the log rank test. All tests were two-sided, and P < 0.05 was considered significant. Data handling and analysis were performed with SPSS version 12.0 software (SPSS Inc., Chicago, IL). The study was approved by all national and, if necessary, local ethics committees. All enrolled patients agreed to participate by completing a written informed consent form after receiving complete oral and written information. One patient refused to be included in the study. Out of 138 consecutive consenting patients with noncirrhotic portal vein thrombosis, 36 were excluded for the following reasons: presentation with a portal cavernoma (n = 33), or with ruptured esophageal varices (n

= 3). Seven patients were included in the descriptive analysis, but were excluded from the therapeutic and prognostic analyses: one received low-dose Protein Tyrosine Kinase inhibitor aspirin, four patients 上海皓元医药股份有限公司 had anticoagulation introduced more than 30 days after diagnosis (at day 35, 55, 65, and 76, respectively), and two have not received anticoagulation. Therefore, 102 patients were included in the descriptive analysis and 95 patients in the therapeutic and prognostic analysis. One hundred two patients

were enrolled and followed-up for a median of 242 days (range, 0–904 days): eight in Belgium, four in Germany, 16 in Italy, 42 in France, 19 in The Netherlands, eight in Spain, and five in Switzerland. Three patients were lost to follow-up before the protocol 1-month evaluation. The main features at diagnosis are presented in Table 1. Most patients had fever or elevated C-reactive protein levels, with or without an inflammatory focus. Moderate yet clinically detectable ascites was observed in only five patients, two of whom developed intestinal infarction. However, clinically undetectable ascites was detected at imaging in 34 patients. The presence of ascites was not associated to atrophy–hypertrophy complex, jaundice, splenomegaly, time to diagnosis, or time to treatment. Splenomegaly was present in 38 (37%) patients, 15 of whom (40%) had a myeloproliferative disorder (MPD), whereas among the 64 patients without splenomegaly, only five (8%) had an MPD (P = 0.001, chi square test). Splenomegaly was not associated with atrophy–hypertrophy complex, jaundice, ascites, splenic vein thrombosis, time to diagnosis, or time to initiation of therapy.

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