Severe wound infection is often characterized by necrotizing skin

Severe wound infection is often characterized by necrotizing skin and soft-tissue infection, including fasciitis and gangrene. V. vulnificus possesses several virulence factors, including the ability to evade destruction by stomach acid, capsular polysaccharide, lipopolysaccharide, cytotoxins, pili, and flagellum. The preferred antimicrobial

BKM120 therapy is doxycycline in combination with ceftazidime and surgery for necrotizing soft-tissue infection. (C) 2010 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.”
“Background: Persistently febrile neutropenic children at risk for invasive fungal infections receive empiric antifungal therapy as a standard of care. However, little is known about the role of echinocandins selleck screening library and liposomal amphotericin B (L-AmB) for empiric antifungal therapy in pediatric patients.

Methods: Patients between the ages of 2 to 17 years with persistent fever and neutropenia were randomly assigned to receive caspofungin (70 mg/m(2) loading dose on day 1, then 50 mg/m2 daily [maximum 70 mg/d]) or L-AmB (3 mg/kg daily) in a 2: 1 ratio. Evaluation of safety was the primary objective of the study. Efficacy was also evaluated, with a successful outcome defined as fulfilling

all components of a prespecified 5-part composite endpoint. Suspected invasive fungal infections were evaluated by an independent, treatment-blinded adjudication committee.

Results: Eighty-two patients received study therapy (caspofungin 56, L-AmB 26), and 81 were evaluated for efficacy (caspofungin 56; L-AmB 25). Outcomes for safety and efficacy endpoints were similar for both study arms. Adverse drug-related event rates [95% confidence interval] were similar between the caspofungin and L-AmB groups (clinical 48.2% [34.7-62.0] versus 46.2% [26.6-66.6]; laboratory 10.7% [4.0-21.9] versus 19.2% [6.6-39.4]). Serious

drug-related adverse events occurred in 1 (1.8%) of caspofungin-treated patients and 3 Selleckchem SB525334 (11.5%) of L-AmB-treated patients. Overall success rates [95% CI] were 46.4% [33.4-59.5] for caspofungin and 32.0% [13.7-50.3] for L-AmB.

Conclusions: Caspofungin and L-AmB were comparable in tolerability, safety, and efficacy as empiric antifungal therapy for persistently febrile neutropenic pediatric patients.”
“Sparganosis is an infection of humans and animals caused by the plerocercoid larvae (spargana) of various diphyllobothroid tapeworms belonging to the genus Spirometra. Sparganosis has been reported sporadically around the world, and a higher prevalence of the disease occurs in several Asian countries, including South Korea, Japan, Thailand, and China. To date, a total of more than 1000 cases of human sparganosis have been reported in 25 provinces in mainland China.

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