2009;47:124–31.PubMed 12. World Medical Association. WMA Declaration Of Helsinki—ethical principles for medical #https://www.selleckchem.com/products/blebbistatin.html randurls[1|1|,|CHEM1|]# research involving human subjects. Adopted by the 18th WMA General Assembly, Helsinki, Finland, June 1964 and amended by the 52nd WMA General Assembly, Edinburgh, Scotland, October 2000. Ferney-Voltaire:
WMA; 2000. 13. International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. ICH harmonised tripartite guideline: guideline for good clinical practice E6(R1). http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Efficacy/E6_R1/Step4/E6_R1__Guideline.pdf. Accessed 19 Nov 2012. 14. State Food and Drug Administration. Guideline for good clinical principles [in Chinese]. http://www.sda.gov.cn/WS01/CL0053/24473.html. Accessed 1 Dec 2009. 15. Center for Drug Evaluation and Research, US Food and Drug Administration. Guidance for industry: bioanalytical method validation. http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm070107.pdf. Accessed 19 Nov 2012. 16. Cabovska B, Cox SL, Vinks AA. Determination of
risperidone and enantiomers of 9-hydroxyrisperidone in plasma by LC–MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2007;852:497–504.PubMedCrossRef 17. Zhang G, Terry AV Jr, Bartlett MG. Sensitive liquid chromatography/tandem mass spectrometry method for the simultaneous determination of olanzapine, risperidone, 9-hydroxyrisperidone, Selleckchem ABT888 clozapine, haloperidol and ziprasidone in rat brain tissue. SDHB J Chromatogr B Analyt Technol Biomed Life Sci. 2007;858:276–81.PubMedCrossRef 18. Shumaker RC. PKCalc: a BASIC interactive computer program for statistical and pharmacokinetic analysis of data. Drug Metab Rev. 1986;17:331–48.PubMedCrossRef 19. Center for Drug Evaluation, State Food and Drug Administration. Guideline for bioavailability and
bioequivalence studies of generic drug products [in Chinese]. http://www.cde.org.cn/zdyz.do?method=largePage&id=2066. Accessed 1 Dec 2009. 20. Center for Drug Evaluation and Research, US Food and Drug Administration. Guidance for industry: bioavailability and bioequivalence studies for orally administered drug products—general considerations. http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM070124.pdf. Accessed 19 Nov 2012.”
“1 Introduction α2-Adrenoceptor agonists such as clonidine and guanfacine are used as adjunctive treatments to psychostimulants in the treatment of attention-deficit/hyperactivity disorder (ADHD) when the response to psychostimulants alone is suboptimal [1–4]. Guanfacine extended release (GXR), a selective α2A-adrenoceptor agonist, is approved by the US Food and Drug Administration as monotherapy and as adjunctive therapy to psychostimulant medications for the treatment of ADHD in children and adolescents aged 6–17 years [5].