(PDF 122 KB) References 1. Rock RB, Olin M, Baker CA, Molitor TW, Peterson PK: Central nervous system tuberculosis: pathogenesis

and clinical aspects. Clin Microbiol Rev 2008,21(2):243–261.PubMedCrossRef 2. Wells CD, Cegielski JP, Nelson LJ, Laserson KF, Holtz LY3039478 molecular weight TH, et al.: HIV Infection and Multidrug-Resistant Tuberculosis–The Perfect Storm. J Infect Dis 2007, 196:S86-S107.PubMedCrossRef 3. Gandhi NR, Moll A, Sturm AW, Pawinski R, Govender T, Lalloo U, Zeller K, Andrews J, Friedland G: Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa. Lancet 2006,368(9547):1575–1580.PubMedCrossRef 4. Padayatchi N, Bamber S, Dawood H, Bobat R: Multidrug-resistant tuberculous meningitis in children in Durban, South Africa. Pediatr Infect Dis J 2006,25(2):147–150.PubMedCrossRef 5. Rubin LL, Staddon JM: The cell biology of the blood-brain barrier. Annu Rev Neurosci 1999, 22:11–28.PubMedCrossRef 6. Be NA, Kim KS, Bishai WR, Jain SK: Pathogenesis of central nervous system tuberculosis. Curr Mol Med 2009,9(2):94–99.PubMedCrossRef 7. Rich AR, McCordock HA: The pathogenesis of tuberculous meningitis. Bull Johns Hopkins Hosp 1933, 52:5–37. 8. Thwaites G, Chau TT, Mai NT, Drobniewski F, McAdam K, Farrar J: Tuberculous meningitis. J Neurol

Neurosurg Psychiatry 2000,68(3):289–299.PubMedCrossRef Thiazovivin 9. Garcia de Viedma D, Marin M, Andres S, Lorenzo

G, Ruiz-Serrano MJ, Bouza E: Complex clonal features in an mycobacterium tuberculosis infection in a two-year-old child. Pediatr Infect Dis J 2006,25(5):457–459.PubMedCrossRef 10. Hesseling AC, Marais BJ, Kirchner HL, Mandalakas AM, Brittle W, Victor TC, Warren RM, Schaaf HS: Mycobacterial genotype is associated with disease phenotype in children. Int J Tuberc Lung Dis 2010,14(10):1252–1258.PubMed 11. Caws M, Thwaites G, Dunstan S, Hawn TR, Lan NT, Thuong NT, Stepniewska K, Huyen MN, Bang ND, Loc TH, et al.: The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis. PLoS Pathog 2008,4(3):e1000034.PubMedCrossRef 12. Hernandez Pando R, Aguilar D, Cohen I, Guerrero Reverse transcriptase M, Ribon W, Acosta P, Orozco H, Marquina B, Salinas C, Rembao D, et al.: Specific bacterial Vistusertib in vivo genotypes of Mycobacterium tuberculosis cause extensive dissemination and brain infection in an experimental model. Tuberculosis (Edinb) 90(4):268–277. 13. Kim KS: Pathogenesis of bacterial meningitis: from bacteraemia to neuronal injury. Nat Rev Neurosci 2003,4(5):376–385.PubMedCrossRef 14. Be N, Lamichhane G, Grosset J, Tyagi S, Cheng Q, Kim KS, Bishai WR, Jain SK: Murine model to study Invasion and Survival of Mycobacterium tuberculosis in the Central Nervous System. J Infect Dis 2008,198(10):1520–1528.PubMedCrossRef 15. Young D: Animal models of tuberculosis. Eur J Immunol 2009,39(8):2011–2014.PubMedCrossRef 16.