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data; DLM has participated in the design of the study and has helped writing the manuscript; ARB participated in the design of the study and revision of the manuscript. All authors have read and approved the final version of the manuscript.”
“Background Salmonella is an enteric pathogen causing major public health problems throughout the world due to the consumption of contaminated food. Nontyphoidal Salmonella species, like Salmonella enterica serovar Typhimurium (STM), are the leading cause of hospitalization and death among the major foodborne pathogens [1]. Antibiotic resistance by Salmonella is dramatically increasing, so the development of an effective vaccine remains a global health priority [2, 3]. Creating a safe and immunogenic vaccine strain is the biggest challenge in developing an effective live-attenuated Salmonella vaccine [4].