Specifically, we assume that only coalescences involving C 1 and C 2 need to be retained in the model, and TPX-0005 manufacturer fragmentation always yields either a monomer or a dimer fragment. This assumption means that the system can be reduced to a generalised Becker–Döring equation closer to the form of Eqs. 2.3–2.6 rather than Eq. 2.1;   (ii) we also assume that the achiral clusters are unstable at larger size, so that their presence is only relevant at small sizes. Typically at small sizes, clusters are amorphous and do not take on the properties of the bulk phase, hence at small sizes clusters

can be considered achiral. We assume that there is a regime of cluster sizes where there is a transition to chiral structures, and where clusters can take on the bulk structure (which LBH589 in vivo is chiral) as well as exist in amorphous form. At even larger sizes, we assume that only the chiral forms exist, and no achiral structure can be adopted;   (iii) furthermore, we assume that all rates are independent of cluster size, specifically, $$ \alpha__k,1 = a , \qquad \qquad \alpha__k,2 = \alpha , \qquad \quad \alpha__k,r =0 , \quad (r\geq2) $$ (2.13) $$ \mu_2 = \mu , \qquad \qquad \mu_r=0 , \quad (r\geq3) , $$ (2.14) $$ \nu_2 = \nu , \qquad \qquad \nu_r=0 , \quad (r\geq3) , $$ (2.15) $$ \delta_1,1 = \delta , \qquad \delta_k,r = 0 , \quad (\rm otherwise)$$ (2.16) $$ \epsilon_1,1 MK-2206 mw = \epsilon ,

\qquad \epsilon_k,r = 0 , \quad (\rm otherwise)$$ (2.17) $$ \xi_k,2 = \xi_2,k = \xi , \qquad \xi_k,r = 0 , \quad (\rm otherwise) $$ (2.18) $$ \beta_k,1 = \beta_1,k = b , \qquad \beta_k,2 = \beta_2,k = \beta , \qquad \beta_k,r = 0 , \quad (\rm otherwise), $$ (2.19)Ultimately we will set a = b = 0 = δ = ϵ so that we PAK5 have only five parameters to consider (α, ξ, β, μ, ν).   This scheme is illustrated in Fig. 1. However, before writing down

a further system of equations, we make one further simplification. We take the transition region described in (ii), above, to be just the dimers. Thus the only types of achiral cluster are the monomer and the dimer (c 1, c 2); dimers exist in achiral, right- and left-handed forms (c 2, x 2, y 2); at larger sizes only left- and right-handed clusters exist (x r , y r , r ≥ 2). Fig. 1 Reaction scheme involving monomer and dimer aggregation and fragmentation of achiral clusters and those of both handednesses (right and left). The aggregation of achiral and chiral clusters is not shown (rates α, ξ) The kinetic equations can be reduced to $$ \frac\rm d c_1\rm d t = 2 \varepsilon c_2 – 2 \delta c_1^2 – \sum\limits_r=2^\infty ( a c_1 x_r + a c_1 y_r – b x_r+1 – b y_r+1 ) , $$ (2.20) $$ \frac\rm d c_2\rm d t = \delta c_1^2 – \varepsilon c_2 – 2 \mu c_2 + \mu\nu (x_2+y_2) – \sum\limits_r=2^\infty \alpha c_2 (x_r+y_r) , $$ (2.