Data were analyzed by using the Statistical Package for Social Sciences (SPSS) version 16.0 (SPSS Inc. – Chicago, IL, USA); p-values of less than 0.05 were considered statistically significant. Complete data of 5,738 students were obtained for the current study, and are reported here. Neratinib Participants consisted of 2,863 males and 2,875 females, with mean (SD) age of 14.7 (2.4) years. Table 1 presents the characteristics of the study participants. The mean (SD) of SBP and DBP were 103.22 (13.89) and 65.87 (10.85) mmHg, respectively. The prevalence of pre-HTN and HTN were 6.9% and 5.6%, respectively. The means (SD) for

SBPHR and DBPHR were 0.68 (0.24) and 0.43 (0.17), respectively. The sensitivity, specificity, and threshold of BPHR for identifying individuals Alectinib price with pre-HTN and HTN are presented in Table 2. The optimal thresholds for defining pre-HTN were 0.73 in males and 0.71 in females for SBPHR, and 0.47 in males and 0.45 in females for DBPHR, respectively. The corresponding figures for HTN were 0.73, 0.71, 0.48, and 0.46, respectively. The related ROC curves for identifying pre-HTN and HTN by BPHR are depicted in Fig. 1, which

demonstrates that for both females and males, the AUC values of SBPHR are greater than those of DBPHR in diagnosing pre-HTN and HTN. The AUC values for the accuracy of SBPHR and DBPHR in diagnosing pre-HTN were 0.84 and 0.80, respectively, and the accuracy of SBPHR and DBPHR in diagnosing HTN was 0.84 and 0.81, respectively, which indicates suitable accuracy. This large population-based study provided a simplified diagnostic tool for primary assessment of BP, and for detecting children

and adolescents in need of further follow-up for identifying pre-HTN and HTN. In the present study, the optimal thresholds for SBPHR and DBPHR for diagnosing systolic/diastolic pre-HTN were 0.73 and 0.47 in males, and 0.71 and 0.45 in females, respectively. These findings are consistent with the some previous studies conducted in children and adolescents, which provided optimal thresholds of BPHR for diagnosing elevated BP, but also suggested the development of these indexes in various populations.8, 9, 14 and 15 In a study among 3,136 Han adolescents aged between 13 and 17 years, the optimal thresholds of SBPHR and DBPHR for defining pre-HTN 17-DMAG (Alvespimycin) HCl were 0.75 and 0.48 for males, and 0.78 and 0.51 for females, respectively. The corresponding figures for defining HTN were 0.81 and 0.57 for males, and 0.84 and 0.63 for females, respectively.8 In a population-based study with 1,173 Nigerian adolescents aged 11 to 17 years, the optimal thresholds of SBPHR and DBPHR for diagnosing pre-HTN were 0.72 and 0.46 in males, and 0.73 and 0.48 in females; the corresponding figures for HTN were 0.75 and 0.51 in males and 0.77 and 0.50 in females.9 In a population-based study of 1,352 Han children aged 7 to 12 years, DBPHR cutoff values for elevated DBP were 0.51 and 0.