Furthermore, considering the difficulties of consuming these nutrients through food and the uncertainties in terms of the absorption of α-linolenic

fatty acid, many studies have been conducted to evaluate this fatty acid as a supplement and its impact on human health using different regimens and populations [40], [41] and [42]. The effects on the prevention of atherosclerosis, chronic hepatitis, psoriasis, rheumatoid arthritis, myocardial infarction, asthma, and diabetes were described, and several studies demonstrated a decrease in proinflammatory cytokines [34], [35], [36], [40] and [41]. Lopez-Garcia [43] observed a buy Metformin 29% decrease of serum CRP in a retrospective study that evaluated the uptake of αLNA through food in healthy women. Using short-term fish oil supplementation, Ciubotaru et al [44] found a 35% decrease of the CRP levels in postmenopausal women. In studies with healthy volunteers and patients with rheumatoid arthritis receiving FO and fish oil, control of inflammation was observed as reflected by a decrease in the mediators of the inflammatory process (cytokines, TNF-α, and IL-1β)

[44]. Flaxseed oil does not contain EPA and DHA fatty acids but is rich in their precursor, αLNA. α-Linolenic acid is partially converted to longer chain n-3 polyunsaturated fatty acids,

such PI3K inhibitor as EPA (20:5n3) oxyclozanide and DHA (22:6n-3); however, at present, it is not known what portion of αLNA undergoes these conversions in the plasma, cells, and tissues [45]. The hypothesis that the α-linolenic fatty acid present in FO is able to reduce inflammation in humans is supported by many studies. The effect of an FO-based diet on the synthesis of TNF-α and IL-1β was tested in healthy volunteers. Over a 4-week period, it was observed that its use inhibited the production of these inflammatory factors by approximately 30%, demonstrating its role as a potential inhibitor of these mediators [40]. Jenkins et al [19] suggested that the intake of grain flaxseed or FO decreases total cholesterol and HDL-c in humans. The effects of FO are mainly observed with regard to LDL cholesterol levels, with the levels of HDL-c and triglycerides being unchanged [46]. Lastly, Singer et al [47] reported a decrease in serum lipids with FO supplementation in patients with primary hyperlipidemia. Surprisingly, there are few studies that have tested therapeutic interventions in the control of the inflammatory state in high-risk populations of uremic patients [14] and [42].