(C) 2013 Elsevier Ireland find more Ltd. All rights reserved.”
“The aim of this study was to investigate the relationship between suicidal behavior and hypothalamic-pituitary thyroid (HPT) axis activity in depressed patients. The serum levels of thyrotropin (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) were evaluated before and after 0800 and 2300 h thyrotropin-releasing hormone (TRH) challenges, on the same day, in 95 medication-free DSM-IV euthyroid major depressed inpatients and 44 healthy hospitalized controls. Compared to controls: (1) patients with a positive suicide history (PSH; n = 53) showed lower basal FT4

(at 0800 h: p < 0.005; at 2300 h: p < 0.03), but normal FT3 levels, while patients with a negative suicide history (NSH; n = 42) showed normal FT4 and FT3 levels; (2) TSH responses to TRH (Delta TSH) were blunted in NSHs (at 0800 Tariquidar mouse h: p < 0.03; at 2300 h: p < 0.00001), but not in PSHs; (3) both NSHs and PSHs showed lower Delta Delta TSH values (differences between 2300 h-Delta TSH and 0800 h-Delta TSH) (p < 0.000001 and p < 0.003, respectively).

Compared to NSHs, basal FT4 levels were reduced in PSHs (at 0800 h: p < 0.002; at 2300 h: p < 0.006). HPT parameters were not significantly different between recent suicide attempters (n = 32) and past suicide attempters (n = 21). However, compared to controls, recent suicide attempters showed lower 2300 h-Delta TSH (p < 0.04) and Delta Delta TSH (p < 0.002) values, and lower basal FT4 values (at 0800 h: p < 0.006; at 2300 h: p < 0.02). Our results, obtained in a large sample of depressed inpatients, indicate that various degrees of HPT axis dysregulation are associated with the history of suicide. (C) 2010 Published by Elsevier Ltd.”
“phi CbK is a

B3 morphotype bacteriophage of the Siphoviridae family that infects Caulobacter crescentus, the preeminent model system for bacterial this website cell cycle studies. The last 4 decades of research with phi CbK as a genetic and cytological tool to study the biology of the host warrant an investigation of the phage genome composition. Herein, we report the complete genome sequence of phi CbK and highlight unusual features that emerged from its annotation. The complete genome analysis of the phi CbK phage provides new insight into its characteristics and potential interactions with its Caulobacter crescentus host, setting the stage for future functional studies with phi CbK.”
“Deimination is a post-translational modification of proteins in which selected arginine amino acids are enzymatically converted to citrullines. Using dual-color immunofluorescence, the present study is the first to examine the frontal cortex of patients with Alzheimer’s disease (AD) versus age-matched controls with an established monoclonal antibody (F95) against peptidyl-citrulline moieties.