CC and MS operated on the patient and took the photographs. All authors read and approved the final manuscript.”
“Background Hemorrhagic shock is commonly defined as a state of insufficient perfusion and oxygen supply of vital organs selleckchem due to loss of blood volume and impaired cardiac preload [1, 2]. In the pre-hospital setting trauma patient’s shock resuscitation and its monitoring is usually based on clinical experience, assessment and a few basic parameters such as level of consciousness, blood pressure, heart rate and capillary filling time. Even if these basic clinical parameters are close to normal, shock on a cellular or organ level

may be present [3–7]. There is little evidence in the literature on basic intervention strategies of fluid therapy [8–10, 6]. The endpoints of

shock resuscitation should be critically assessed, and resuscitation from shock considered completed only when anaerobic metabolism and tissue acidosis have been successfully reversed. The key therapeutic factor to prevent the development of multiple organ failure (MOF) is the normalisation of disturbed microvascular perfusion and oxygen supply. Military experience and clinical and laboratory studies provide new knowledge and tools for pre-hospital and early hospital use to reverse hypovolaemia CFTRinh-172 mouse and hypoxia more effectively. Early triage, early monitoring, small-volume resuscitation with hypertonic saline, haemoglobin-based oxygen carriers, medical informatics, damage control surgery and definitive interventional radiology can be promising methods to improve the patient care [8]. Repeated measurements of arterial

blood gases, lactate and haemoglobin give important information for diagnosis and follow-up. Serial haemoglobin measurements assess ongoing bleeding, and signs of metabolic acidosis indicate inadequate oxygen supply and anaerobic metabolism at cellular level, helping to BEZ235 evaluate the severity of shock. Pre-hospital blood gas values could as well be considered as a tool for early triage and even as criteria for trauma team activation in a hospital or a trauma centre. This study was conducted to assess, whether Molecular motor measurements of blood gases before and after pre-hospital fluid resuscitation provide useful information about efficacy of resuscitation and sufficiency of perfusion and oxygenation in the tissues. The second focus of this study was to evaluate the use of small-volume resuscitation with 7.5% hypertonic saline (HS). Methods In this randomised prospective preliminary study we compared two different pre-hospital fluid resuscitation strategies for severely injured patients as well as the usability and information provided by a portable blood gas analyzer.