In general, the ALK fusion protein is associated with a good prognosis. The most common sites of ALCL involvement are lymph nodes, followed by skin, bone and soft tissue. Gastrointestinal ALCL was rarely reported. Herein we for the first time documented macroscopic and NBI-based magnified endoscopic findings of gastrodundenal lesions. Contributed by “
“Harold O. Conn, LDE225 nmr M.D., a world-renowned hepatologist, President of the American Association for the Study of Liver Diseases in 1972-1973 and a 50-year faculty member of the Yale University

School of Medicine and the Yale Liver Program, died on October 9 at age 85 in Pompano Beach, Florida 1. Conn was a pioneer in the basic understanding and treatment of cirrhosis and its complications and published more than 200 peer-reviewed articles in national and international medical journals. His major scientific contributions to the field related to studies on the accuracy of serum ammonia measurements, characterization of spontaneous bacterial peritonitis, the evaluation of prophylactic portacaval shunts in clinical trials, the radiologic and endoscopic evaluation of esophageal varices, and the treatment of portal systemic encephalopathy with lactulose. He was the first to use the term “spontaneous bacterial

peritonitis” and was responsible for the frequently quoted “West Haven” criteria of hepatic encephalopathy. He was frequently asked to editorialize and often used a unique sense of humor to make the articles more C646 mouse enjoyable. He published 17 original articles, reviews, and editorials in the New England Journal of Medicine and many others in prominent journals, including HEPATOLOGY and Gastroenterology. He was a consummate critic and editorialized extensively on topics that ranged from clinical study design, assessment of the accuracy

or safety of diagnostic procedures, including effectiveness of liver biopsy in liver cancer, Astemizole and the use and risks of the Sengstaken-Blakemore tube for the treatment of bleeding esophageal varices. Conn was born in Newark, New Jersey, on November 16, 1925, the fourth of four children of Joseph and Dora Conn, second-generation American parents who had emigrated from Southeastern Europe. He was an all-state high school swimmer who left New Jersey to earn B.S. (1946) and M.D. (1950) degrees from the University of Michigan thanks to the financial support of his older brother, Jerome Conn, a physician and faculty member at the Ann Arbor School. After interning at the Johns Hopkins Hospital in Baltimore, Maryland, he was the chief resident at Yale-New Haven Hospital and earned a 2-year fellowship with Dr. Gerald Klatskin at Yale, one of the early founders of the discipline of hepatology. Later, Conn set up his own liver unit at the West Haven Veterans Affairs Hospital, where many future hepatologists were trained, including two of the authors of this obituary (R.J.G. and G.G-T.).