Sometimes oral NSAIDs drugs are restrictedly applied mainly for t

Sometimes oral NSAIDs drugs are restrictedly applied mainly for the reason to stimulate patient’s gastric mucosa. Intravenous flurbiprofen axetil injection could avoid this side effect. In all of 1089 cases, the side effect incidence rate was very low about 2.9% [18]. Most side effects were in gastrointestinal tract such as nausea, vomit, diarrhoea or in neuropsychosis such as fever, fear cold, https://www.selleckchem.com/products/MK-1775.html sleepiness, etc. Few cases expressed as subcutaneous bleeding or pain in the injecting site. Perhaps our cases were insufficient,

no side effect of flurbiprofen axetil was found in this study. Conclusion In general, Selleck LY2874455 cancer pain is considered as chronic. The pain intensity ranges from mild to severe and present for a long time. Harmless approach to therapy such as by oral or by cutaneous are suggested by WHO. But, for some reasons as constipation and psychosomatic symptoms, there has many patients whose can not take drugs by oral, or can not be used cutaneous anaesthetic drugs, intravenous flurbiprofen axetil could exactly remedy the anaesthetic drug’s shortcoming, and let itself to be an important switch drug. Acknowledgements The authors thank other staffs working in the department of medical oncology,

the first affiliated hospital of Anhui medical university for they supported our work. References 1. Villars P, Dodd M, West C, Koetters T, Paul SM, Schumacher K, Tripathy D, Koo RAD001 purchase P, Miaskowski C: Differences in the prevalence and severity of side effects based on type of analgesic prescription in patients with chronic cancer pain. J Pain Symptom Manage 2007, 33: 67–77.CrossRefPubMed 2. Fallon M, McConnell S: The principles of cancer pain management. Clin Med 2006, 6: 136–139.PubMed Astemizole 3. Roszkowski MT, Swift JQ, Hargreaves KM: Effect of NSAID administration on tissue levels of immunoreactive prostaglandin E2, leukotriene B4, and (S)-flurbiprofen following extraction of impacted third molars. Pain 1997, 73:

339–345.CrossRefPubMed 4. Karasawa F, Ehata T, Okuda T, Satoh T: Propofol injection pain is not alleviated by pretreatment with flurbiprofen axetil, a prodrug of a nonsteroidal anti-inflammatory drug. J Anesth 2000, 14: 135–137.CrossRefPubMed 5. Yamashita K, Fukusaki M, Ando Y, Fujinaga A, Tanabe T, Terao Y, Sumikawa K: Preoperative administration of intravenous flurbiprofen axetil reduces postoperative pain for spinal fusion surgery. J Anesth 2006, 20: 92–95.CrossRefPubMed 6. Mizuno J, Sugimoto S, Kaneko A, Tsutsui T, Tsutsui T, Zushi N, Machida K: Convulsion following the combination of single preoperative oral administration of enoxacine and single postoperative intravenous administration of flurbiprofen axetil. Masui 2001, 50: 425–428.PubMed 7.

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