The association of PCDH8 methylation with the clinicopathological

MK-8931 mw features is summarized in Table 2. The promoter methylation of PCDH8 in NMIBC tissues was correlated with, advanced stage (P = 0.0138), high grade (P = 0.0010), larger tumor size (P = 0.0482), tumor recurrence (P < 0.0001) and tumor progression (P < 0.0001) significantly. However, the promoter methylation of PCDH8 was not correlated with age, gender, and tumor number. Table 2 Relationship between PCDH8 methylation and clinicopathological characteristics in NMIBC (n = 233) Features Variables No. M (%) U (%) P Age 65 86 46(53.5) 40(46.5) 0.7342 >65 147 82(55.8) 65(44.2)   Sex Male 161 94(58.4) 67(41.6) 0.1135 Female 72 34(47.2) 38(52.8)   Number Single 142 82(57.8) 60(42.2) 0.2814 Multiple 91 46(50.6) 45(49.4)   Size ≤3 cm 139 69(49.6) 70(50.4) 0.0482 >3 cm 94 59(62.8) 35(37.2)   Grade G1/ G2 144 67(46.5) 77(53.5) 0.0010 G3 89 61(68.5)

28(31.5)   Stage Ta 95 43(45.3) 52(54.7) 0.0138 T1 138 85(61.6) 53(38.4)   Recurrence No 127 40(31.5) 87(68.5) <0.0001 Yes 106 88(83.0) 18(17.0)   Progression No 175 80(45.7) 95(54.3) <0.0001 Yes 58 48(82.8) 10(17.2)   M: Methylation; U: Unmethylation. The impact of PCDH8 methylation on the clinical outcome of NMIBC To examine if PCDH8 promoter methylation is a potential predictor of the prognosis in NMIBC, the recurrence-free survival, progression-free MLN2238 in vivo survival and five-year overall survival was analyzed, and the NMIBC patients was divided into two subgroup according to PCDH8 methylation status. Kaplan-Meier survival analysis and log-rank test suggested that NMIBC patients with PCDH8 methylated had significantly shorter recurrence-free survival (P < 0.0001; Figure 2), progression-free survival (P < 0.0001; Figure 3) and five-year overall survival (P = 0.0262; Figure 4) than patients with PCDH8 unmethylaed

very respectively. Moreover, EX 527 price multivariate Cox proportional hazard model analysis indicated that PCDH8 promoter methylation in tissues was an independent predictor of shorter recurrence-free survival (P < 0.0001; Table 3), progression-free survival (P =0.0036; Table 4) and five-year overall survival (P = 0.0015; Table 5). Figure 2 Correlations between PCDH8 methylation and recurrence-free survival in NMIBC patients. Patients with PCDH8 methylated showed significantly shorter recurrence-free survival than patients without (P < 0.0001, log-rank test). Figure 3 Correlations between PCDH8 methylation and progression-free survival in NMIBC patients. Patients with PCDH8 methylated showed significantly shorter progression-free survival than patients without (P < 0.0001, log-rank test). Figure 4 Correlations between PCDH8 methylation and five-year overall survival in NMIBC patients. Patients with PCDH8 methylated showed significantly shorter five-year overall survival than patients without (P = 0.0177, log-rank test).