Thus, the recording of pressure ratio during the cardiac cycle in UMI-77 research buy a brachial artery can provide only indirect information of pressure/strain ratio in carotid artery. Considering this argument, it seems logical to evaluate carotid artery wall dynamics by ultrasound measurements of arterial wall structure and movements in a strictly precised vascular area. Apart from the blood pressure as the major determinant of vessels stretch the blood flow shear stress could play the important role in arterial distensibility. Endothelial cells are the primary vascular cells exposed to shear stress from the friction

of laminar blood flow against the vessels wall. One of possibilities to detect the influence of endothelium and smooth muscle on arterial distensibility or stiffness is the recording of intima–media thickness (IMT) and its relation to vessels diameter (Fig. 1). The most popular are the measurements: IMT to vessel’s radius ratio: IMTRadius=2×IMTmean internal diameter, Mean circumferential wall stress (MCWS) [19] MCWS=Mean BP× mean internal diameter2×IMT IMT and MCWS are indicative for changes in both endothelium and smooth muscle wall’s layers

since even high resolution ultrasound technique can provide the image of intima–media complex [22]. This technique with the phased tracking can obtain the measurements even of minute changes in IMT. From the maximum change in thickness during one mTOR inhibitor therapy heartbeat, the radial strain of each assigned layer in the artery wall (ɛr) is calculated as: εr=hmax−hminhmaxwhere hmax and hmin – maximum and minimum thickness of an assigned layer in the wall, respectively [23]. Commonly used the IMT measurement become the marker of early stage of decreased elasticity or increased stiffness of arterial wall. Significant correlations between increased IMT and the presence of arterial hypertension, hyperlipidemia, arterial atherosclerosis,

diabetes mellitus and aging had been proven in many studies [24]. IMT and carotid artery stiffness became useful predictors of the risk of cerebrovascular and cardiovascular events [25]. Some results of the correlations between IMT and arterial distensibility indicate that gender- and age-related differences can be manifested even in young, healthy adults and may be identified with techniques that assess carotid distensibility across a range PD184352 (CI-1040) of pressures [26]. Although smooth muscle tone is a key determinant of mechanical properties of arteries its assessment in humans is technically limited and direct contribution of vascular smooth muscle to artery elastic mechanics is controversial [26] and [27]. Detecting the influence of tone on arterial properties is possible by applying sympathetic/parasympathetic stimulating test to the measurements of wall elastic properties. There is the certain association between the changes in carotid arterial distensibility and autonomic imbalance.