[1,3] Interpreting the literature is complicated by variations in terminology. Twenty-six different definitions

of medication error were identified in a review of 45 medication error studies.[7] The prevalence of errors in these studies ranged from 2–75%, but no associations were found between prevalence and definitions of error.[7] In studies looking at all types of medication errors, prescribing errors accounted for the highest percentage,[7] although the administration stage has been identified as the point at which the most harm to patients occurs.[4] The most common dispensing errors found in community and hospital pharmacies are dispensing the wrong drug, strength, form or quantity, and labelling medication with incorrect directions.[8] VE-822 mw FK506 cell line All but the last of these errors can occur as a result of medications having similar looking or similar sounding names. Rates of dispensing errors vary widely depending on context (community or hospital pharmacy), whether prevented or unprevented errors are measured, how errors are defined and how rates are calculated.[8] Estimates range from less than 0.5% up to 24% of medications dispensed.[8]

While the effects of medications errors vary widely, they have the potential to cause adverse drug events, some of which can have serious consequences for patients.[9] Medicines being incorrectly chosen and administered inadvertently because of similar sounding or looking names has great potential to cause harm.[10] Tamoxifen/tenoxicam is an example of generic name potential confusion. Up to 25% of medication errors in the USA are reported to involve drug name confusion[11,12] and up to 33% are attributed to packaging and/or labelling confusion.[12] Both orthographic

(i.e., spelling) and phonological (i.e., sound) similarity increase P-type ATPase the probability of name recognition errors among both experts and novices.[11] Australia has a National Medicines Policy, comprising four arms,[13] one of which is Quality Use of Medicines (QUM). A number of programmes and activities have been pioneered in Australia to improve how medicines are used safely and effectively. These have been collated and documented on the QUMmap (http://www.qummap.net.au). The Australian National Medicines Policy Committee commissioned the study reported here, which evaluates the issue of medicine names that may cause confusion by their similarities, either by sounding similar or by looking similar when written. This issue has international implications for clinical practice.