7-mg deslorelin implant. Six healthy, adult dogs of various breeds and body weights were implanted with deslorelin (Suprelorin, Virbac) and followed every 2 weeks with semen and blood collections. Semen quality remained stable or even improved during the first month following treatment and then showed a progressive decline until the end of the study, except for sperm morphology, which was unaffected by the treatment. Complete sterility

was achieved on post-treatment days 70, 84, 60, 23, 51 and 40 for dogs find more 1 to 6, respectively. The 4.7 mg deslorelin implant caused a significant (p<0.05) decrease in serum testosterone as well as sperm motility. Our results (i) confirm the efficacy of deslorelin in causing reversible sterility in male dogs, (ii) confirm and provide details about endocrine and seminal parameters involved in this process and (iii) contribute to

define the interval between treatment and achievement of complete sterility. Practitioners should be aware that such interval may be longer than 2 months in some cases, and that fertility may actually be increased during the first 24 weeks post-treatment.”
“Background Mechanisms underlying a reduction in coronary flow reserve (CFR) in hypertrophic cardiomyopathy (HCM), especially apical HCM (ApHCM), are elusive. This study set out to evaluate mechanisms underlying a reduction in CFR in https://www.selleckchem.com/products/gsk923295.html 2 HCM subtypes. Hypothesis Mechanisms for CFR reduction in HCM are different between the 2 subtypes of HCM. Methods Thirty-one patients with asymmetrical septal hypertrophy (ASH), 43 with ApHCM, and 27 healthy volunteers were recruited. Mean diastolic coronary

flow velocity (CFmv) was monitored before and after adenosine infusion by transthoracic echocardiography in the mid-to-distal left anterior descending coronary artery. Coronary flow reserve was defined as the ratio between CFmv before and after adenosine infusion. Left ventricular mass index and stress myocardial perfusion were assessed by cardiac magnetic resonance imaging. Results Selleck AG-881 Although basal CFmv was higher in ASH patients than in healthy controls (P < 0.05), it was similar in ApHCM patients and controls (P = 0.85). Poststress CFmv was significantly lower in both HCM subtypes than in controls (P < 0.05). Consequently, CFR was higher in controls than in ASH or ApHCM patients (P < 0.05). When HCM patients were stratified into 2 groups based on the presence of CFR impairment, no difference was observed between these 2 groups in terms of left ventricular mass index by cardiac magnetic resonance imaging. Multivariate logistic regression analysis identified basal CFmv as the only independent variable associated with CFR reduction in HCM (r2 = 0.49, P < 0.001).