The main predictors included baseline levels of diurnal cortisol secretion and control strategies used to manage physical health threats. Results: A large

increase in functional disabilities was observed among participants who secreted elevated baseline levels of cortisol and did not use health-related control strategies. By contrast, high Selleck SU5416 cortisol level was not associated with increases in functional disabilities among participants who reported using these control strategies. Among participants with low cortisol level, there was a relatively smaller increase in functional disabilities over time, and the use of control Strategies was not significantly associated with changes in functional disabilities. Conclusions: The findings suggest that high cortisol level is associated with an increase in older adults’ functional disabilities, but only if older adults do not engage in adaptive control strategies.”
“Objective: The purpose of the present study was to determine the effects of modafinil, escitalopram, and modafinil + escitalopram administration on neurocognition Talazoparib ic50 in a sample of long-term, high-dose cocaine users.

Method: Sixty-one cocaine-dependent individuals were randomly assigned to receive placebo (n = 14), modafinil, 200 mg, once daily (n = 16), escitalopram, 20 mg, once daily (n = 16), or modafinil and escitalopram, once daily (n = 15), for

five days on an inpatient basis. Urinanalysis was used to confirm abstinence from cocaine on the day of admission and the next five days. Baseline neurocognitive assessment,

which included measures of attention/information processing, episodic memory, and working memory, was conducted immediately after the washout phase and prior to the administration of modafinil. The follow-up assessment was conducted after participants had received modafinil or placebo for five days.

Results: Repeated-measures, mixed model analysis of variance showed that modafinil administration was associated with significantly improved performance on two measures selleck screening library of working memory span (mean n-back span, maximum n-back span) and a trend toward significant improvement on a measure of visual working memory (visual accuracy) and two measures of sustained attention, consistency of response time (Variability) and reduced impulsivity (Perseveration). Modafinil administration did not modulate performance on measures of information processing speed or episodic memory. Escitalopram did not modulate performance on measures of cognition, either alone or in combination with modafinil.

Conclusions: This study provides initial data showing that, in a sample of long-term, high-dose cocaine users, administration of psychotropic medications, such as modafinil, can improve performance on measures of working memory.